Sunday, September 30, 2012

Samsung Galaxy Note 2 video hands-on and initial review

Android Central

With the Samsung Galaxy Note 2 hitting select UK stores imminently, it's time for us to go hands-on with the finished product. We first tested out the Galaxy Note 2 at IFA in Berlin in late August, and it's taken just over a month to finalize the device. The original Samsung Galaxy Note has proved a surprising success over the past year. With the second-gen Note being bigger and more powerful than ever, Samsung will be hoping its efforts are reflected in even stronger sales this time around.

Check out our first hands-on video with the final, retail Galaxy Note 2 after the break, along with a quick overview of the device.

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Source: http://feedproxy.google.com/~r/androidcentral/~3/5QZO9h3S4_8/story01.htm

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Samsung wins reconsideration of Galaxy Tab sales ban

US-APPLE-SAMSUNG-RULING:Samsung wins reconsideration of Galaxy Tab sales ban

SAN FRANCISCO (Reuters) - A U.S. appeals court ruled on Friday that a lower court should reconsider a sales ban against Samsung's Galaxy Tab 10.1 won by Apple in a patent dispute with the South Korean electronics maker.

The injunction was put in place ahead of a month-long trial that pitted iPhone maker Apple Inc against Samsung Electronics Co Ltd in a closely watched legal battle that ended with a resounding victory for Apple last month on many of its patent violation claims.

However, the jury found that Samsung had not violated the patent that was the basis for the tablet injunction and Samsung argued the sales ban should be lifted. U.S. District Judge Lucy Koh said she could not act because Samsung had already appealed.

In its ruling on Friday, the Federal U.S. Circuit Court of Appeals in Washington said Koh could now consider the issue.

The decision comes just a month before the South Korean corporation is expected to unveil the second generation of one of its most successful devices, the stylus-equipped Note.

The Galaxy 10.1 is an older model, but the ban still hurts Samsung in the run-up to the pivotal holiday shopping season.

The world's top two smartphone makers are locked in patent disputes in 10 countries as they vie to dominate the lucrative market, which is growing rapidly.



A U.S. jury found during the just-concluded trial that Samsung had copied critical features of the iPhone and iPad and awarded Apple $1.05 billion in damages.

(Reporting By Dan Levine; Editing by Lisa Von Ahn. Editing by Andre Grenon)

Source: http://www.itbusinessnet.com/articles/viewarticle.jsp?id=2218269

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Marine-turned-country star sings about PTSD

By Bill Briggs, NBC News contributor

Everything you see in the music video happened to Marine-turned-country-singer Stephen Cochran: Pushing the girl away, boozing into oblivion, the gun on the blanket. It all went down last year.?

Courtesy of Stephen Cochran

Stephen Cochran, a former Marine recon scout and now a country-music singer, has penned a new song about PTSD - combat-related symptoms that almost claimed his life in 2011.

Even the actor who portrays Cochran is, himself, a former Marine and Iraq veteran who knows of post-traumatic stress, who has wrangled with identical demons. The actor was not acting.

The only on-screen tweak from reality was?the type firearm shown. In his dimmest hour, behind a locked door in his Nashville home, exhausted, alone, and telling himself: ?I?m done,? Cochran rested a loaded shotgun against his bed.

?I was just trying to get the nerve. I had it planned out,? Cochran told NBC News. ?I didn?t know what was wrong with me. I was tired of taking all these pills. I was going through a breakup. Couldn?t write anymore. Watching everything fall apart. I was ready to check out.?


Then: salvation, and a surreal rescue scene worthy of an epic ballad. His dog, Semper Fi, began scratching relentlessly at his door, bloodying her paws. Next, Cochran?s ex-fianc? unexpectedly entered the house, simply to retrieve a forgotten item, he said. She saw the anxious dog. She expected the worst. She barged into the bedroom, spotted the gun and physically restrained Cochran.?

But from anguish came inspiration. Amid an existence long blurred by PTSD ??the residue of Afghanistan firefights, Marine buddies lost in combat, and his own nearly fatal injury???one question blazed in Cochran's head. He jotted it down: ?How do you paint a picture back in focus??

?It was the only way I could describe trying to put your life back together, literally trying to do the impossible,? he said.

Around that single thought, Cochran penned an entire song, ?Pieces,?an ode to the blackness from which he was aching to escape, a tale of reconnecting the scattered fragments of his shattered world, and a message of solidarity for his military brothers and sisters. The single ? part of a CD with the same title???will be released in this country on Nov. 11. The song already has charted in Europe.

?It?s not just my story. So many of us think about (suicide) because you just get so tired, so tired of being the crazy guy. Or of hearing: ?He?s weird.? Or of hearing: ?We can?t hire you because we really don?t know what post-traumatic stress is and you might come back and kill us all.?

?I really wrote it as my own healing, for what I was going through,? added Cochran, 33, who teamed with fellow musician Trevor Rosen to complete the song. It took them only 15 minutes.

But after playing it at several veterans? benefits, Cochran heard from service members up and down the chain of command how they, too, connected with the lyrics. That feedback has turned ?Pieces? into the soundtrack of the singer?s ongoing crusade.

?We have an epidemic of suicides in the military right now.?At this point, we are physically losing both of these wars in the United States of America, not overseas.

Related: First opera about Iraq War reaches out to veteran suffering from PTSD

?If we want to stop our suicides, we need a complete overhaul in our ?warrior? terminology in this country, in the way we train our families (how to relate with homecoming veterans). That?s what I want to start with ?Pieces,? and the video. I want to get a bridge between our civilian population and the veterans. And I want to reach into the rooms of some of these guys and girls ??who are just sitting in the dark and watching TV all day like I did???and let them know: You?re not alone.?

Perhaps the most ironic thread of Cochran?s story coils back to the days of his first, true musical success. In 2007, one year after retiring from the Marines, he scored a country hit with ?Friday Night Fireside,? the culmination of a childhood dream for a guy raised in Nashville. The accompanying video was voted No. 1 by Great American Country?fans for five straight weeks.

courtesy of Stephen Cochran

After his the light-armoured vehicle crashed in Afghanistan, Stephen Cochran fractured vertebrae and suffered a traumatic brain injury in 2004. Told he would never walk again, an experimental procedure by VA surgeons restored his steps.

Two years later, Cochran became the national spokesman for research and development at the U.S. Department of Veterans Affairs ??his thank you for a successful, experimental surgery performed by VA surgeons who repaired his broken back. In 2004, Cochran had splintered several lumbar vertebrae when the vehicle in which he was riding through southern Afghanistan slammed into gaping hole that once held an anti-tank mine. He couldn?t feel or move his legs for months, and was told by doctors that he?d never take steps again. He walked.

The former Marine reconnaissance scout, part of the U.S. force that first knocked the Taliban out of Afghanistan?s Helmand Province, next teamed up with the VA to become its national co-chair for voluntary service. In that role, Cochran toured America, urging veterans to seek help for combat stress, ?to let them know you don?t have to suffer in silence,? recalled Rosetta Fisher-Oliver, the VA?s chief of voluntary service for Tennessee and for parts of Kentucky and Georgia.

In 2011, Cochran recorded the music video ?Hope??for the VA to try and cement his get-help pleas to fellow troops. What few knew: Cochran was losing his own hope.

?We worked on that video together, and the week he was supposed to make the video, I tried to get in touch with him, just to check to see that he was going to be on time,? said Fisher-Oliver.

She was unable to reach him, however, because Cochran was by then seeking treatment ? after reaching the brink of suicide in his bedroom.

?Here?s a person who?s trying to get the message out and he?s still struggling with issues too,? she said. ?He later told me: ?I almost wasn?t here.? ?

Cochran now acknowledges that he carried ?almost dual personalities? during that time. In front of fellow veterans and fans, he sang, smiled, shook hands and signed autographs. ?But I also had to deal with this monster I have inside my head and inside my gut, all day.? At home, his family and his then-fianc?, he admitted, took the brunt of his mood swings and emotional detachment.

courtesy of Stephen Cochran

After breaking his back in Afghanistan, Cochran was greeted by a fellow Marine. He later regained the ability to walk.

?You?re screaming out: Please help me understand what I?m going through, because I have no clue! That?s why you see the high number of divorces in the military,? Cochran said. ?I told my fianc?: ?I don?t know what I?m dealing with so the best thing for you to do is just leave and you?ll thank me later.' ?

She left.

But in what could have been Cochran?s final minutes, she came back, and burst into his bedroom.

After Cochran artfully turned that horrid moment into a song, he met the man picked to portray his downward spiral in the ?Pieces? video: Daniel Dean, a Nashville songwriter and actor. He also looks a bit like Cochran. He seemed like a logical choice.

In talking with Dean, though, Cochran learned that the man was a Marine sniper who did three tours in Iraq. And they both had lived for years with the lingering anxieties that often remain for veterans who log months of combat exposure.

?He told me: 'This is my story, too,'? Cochran remembers. ?That dude lived that.?

They also agreed with the concept that ?Pieces? would be not just the first music video to delve so deeply into PTSD. It would break ranks with dozens of other standard, country-music videos about the U.S. military ? mini movies that often include battle scenes that, some critics say, glorify war.

?Stephen does country music and so do I, and there?s a lot of military songs and a lot of them are pretty much B.S.? Dean said. ?You?ve got the Toby Keith type stuff?and that?s all right for what it is. But very rarely does a song hit a military person the way this one does.

?Just because it?s real. It?s one of the things I doubt you?ll hear any of the other country stars singing about. It?s (usually) more of the patriotic angle. Most military members aren?t songwriters like Stephen and I. So, I guess that lets us be able to sing things that you can?t say or can't deal with.??

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Source: http://usnews.nbcnews.com/_news/2012/09/28/14128747-a-country-song-about-ptsd-all-youve-got-left-are-these-pieces?lite

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Saturday, September 29, 2012

Video: Drug lab scandal rocks Massachusetts



>> outside minneapolis a community is reeling after a man who was fired from his job yesterday morning returned to work with a gun, opening fire on his colleagues. when it was all over, six people were dead, including the gunman. nbc's kevin tibbles reports.

>> reporter: today, police removed the body of those killed in yesterday's killing spree. it happened at accent signage systems, where an employee let go that morning returned and opened fire.

>> the obvious signs of conflict in there, it was a hellish time.

>> reporter: the shooter killed five, among them the company's owner, a grandfather.

>> reuben was a very important part of this business, he was born in israel and came to this country to live the american dream .

>> reporter: an immigrant who started his business in his basement.

>> he was something who climbed the ladder of success in his business and tried to help people in the business, as well.

>> reporter: another person, the driver of the ups truck , on the premises. he was described as a gentle spirit, with ups for nine years.

>> he is well known to many.

>> reporter: the suspected gunman killed himself in the basement, his parents say he struggled with mental illness.

>> our hearts go out to the families of the people killed, and those wounded in this tragedy. nothing we can say can make up for their loss.

>> reporter: neighbors who watched in horror as employees ran for their lives, are grateful nobody else was dead.

>> i am grateful there were so many people who did survive and save each other's lives.

>> reporter: tonight, two shooting victims are in the hospital in critical and serious condition. as a community mourns. kevin tibbles, nbc news, minneapolis.

Source: http://video.msnbc.msn.com/nightly-news/49218873/

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Israel PM tells coalition partners to back budget or face poll

JERUSALEM (Reuters) - Israeli Prime Minister Benjamin Netanyahu has told his coalition partners he will have to call an early election if they do not back a "responsible" budget he must present by the end of the year.

Netanyahu said he would start meeting coalition partners after he returns home from New York on Sunday. Failure to pass the budget by December 31 would mean bringing forward a national ballot currently scheduled for October 2013.

"I'm sorry to say that it depends on each and every (coalition member)," Netanyahu told Israel's Channel 1 television in an interview recorded in New York on Friday and aired in Israel on Saturday night.

Netanyahu travelled to the United States where he addressed the United Nations General Assembly on Thursday, with Iran's nuclear programme the highlight of his speech.

"I need a responsible budget and I am saying to my coalition partners: if you are going to go all the way (with me) and don't only pay lip service ... then there will be a responsible budget, but if I will see that this is not the case we will have to call elections. I hope that they will go for the responsible (option)," the Israeli leader said.

Netanyahu has been under pressure from Israel's central bank to maintain fiscal credibility at a time when the economy is slowing and tax revenues are falling short.

His right-wing coalition includes five partners who control 66 seats in the 120-seat parliament. Some of the partners, including ultra-Orthodox religious parties, have been reluctant to agree to budget cuts and spending priorities.

Two weeks ago, Stanley Fischer, the central bank governor, urged Netanyahu's coalition to deliver the budget for ratification by next month, citing concerns about economic stability.

"The prime minister will have to decide whether he can submit the budget by the mid- to end October. He needs to lower the level of uncertainty," Fischer told the Maariv newspaper.

"I understand that the decision is a complex one, but it is better to have a budget by now. If not, a budget that will be approved after the elections will include a conservative fiscal policy," Fischer added in the interview.

Israel's Finance Minister Yuval Steinitz told Reuters in an interview earlier this month it would be possible to know if a budget could be passed at the end of the week-long Jewish festival of Sukkot which begins on Sunday. (Writing by Ori Lewis; Editing by Andrew Osborn)

Source: http://news.yahoo.com/israel-pm-tells-coalition-partners-back-budget-face-205226808--business.html

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Friday, September 28, 2012

railway woodcutting: Lucy Melford: Card games - uvyvuvo's posterous

I like playing cards, but sadly this is no longer a usual family passtime, and not many people now seem to play cards in the home, or even know how. I suppose that anyone brought up in an era where money was tight, entertainments were fewer, and home-made entertainment was important, will know a wide range of card games for varying numbers of players, including patience games for only one player. Especially if they were in the war, or had a job where hanging around for hours on end for an emergency call was the routine: cards helped to fill in the waiting time.

I first learned about cards as a young child in the 1950s, because my Dad and my Uncle W--- were inveterate players. And on holiday - in the chalet say - the parents would all play Whist or similar games. Mum wasn't very good; but she knew enough to play a decent game; and an ability to take part in a game of cards was definitely part of one's social repertoire, as much as knowing how to dance, or how to hold a cigarette as done in the movies (which we called 'the pictures'). Cards might bore you rigid, but nevertheless it was something you had to be prepared to join in with. People who refused to take part in a game were thought odd and awkward. Like making too much of a fuss about not watching a well-loved TV programme in the days when people really did sit enthralled by I Love Lucy, and The Phil Silvers Show (that is, Sergeant Bilko), and The Flintstones, and The Black and White Minstrel Show.

There were many, many card games to play, full of interest, and the ones suitable for children, like Snap, were always lots of fun. I staunchly maintain that I didn't have a satisfactory childhood - you can easily guess why in retrospect - but I must admit that family card games were something I always enjoyed, whatever the company. I was never very good at them, but I was better than Mum was, and it was always a pleasure, and a delicious taste of grownupness, to play Solo Whist with Dad and Uncle W---. They were both gentle, good-tempered men, who studied the game and were good at it. When they won, they'd comment on their very good luck (not their skill); and when they lost, they did so with no more than a rueful smile. It was a world of laughing and chuckling, of winks and twinkling eyes, without strife and inquests or any suggestion of bad feeling.

If I ever thought about it, I saw a game of cards as a ritual in which the rules of the game overrode any personal feelings, a ritual that made people friends, not enemies. I associated my childhood card games with enduring stability and the best of family life.

But then I never took part in cut-throat backroom games for money, never felt the motification of being cheated, and of being afraid to challenge the perpetrators. In the course of my job, I once investigated a London bookmaker who had been cashiered from the RAF for gambling. I was able to prove that he was now taking a percentage off the Revenue. We agreed on that percentage, and settled on that basis, after a cross and contentious interview at which I felt not only soiled by the man himself, but by his equally shysterish accountant. My Revenue experience, whether it was the girl early on who was a croupier on a cruise ship, or the dentist much later who claimed to make a large income from private games of backgammon, all made me associate gambling with sleaze and moral corruption.

I'm sorry to say that. After all, I used to like playing Pontoon for matchsticks when young. I thrilled to the glamorous descriptions of casino gambling, and cards with M at Blades, in the James Bond books, especially Casino Royale (Baccarat, against Le Chiffre) and Moonraker (Bridge, against Hugo Drax).

But during my teens I read Scarne's Complete Guide to Gambling - which I still possess. This was a pre-computer age treatise, on all kinds of gambling from poker to horse-racing; all about craps, blackjack, roulette and other casino games; all about sweepstakes and the numbers game; all about one-armed bandits, all about fairground rackets; with a section on how to cheat. Fascinating stuff. I absorbed it. It was one area in which I felt well-informed as I grew up, and apart from some drunken games of three-card brag with friends after a take-away chinese late at night during the mid-1970s, with nothing but pennies at stake, I kept well away from gambling. The 'glamour' entirely faded when confronted (in my Revenue career, though thankfully not as a steady diet) with real people who did it for real money in real life, and cheated, and then lied about their winnings (or losses) to my face. Even if they could produce scorecards and silver cups. Even if they could claim to be close friends of John Aspinall. Ugh. Or the pathetic Kebab House owner who concealed ?300 a week of his takings so that he could blow it on gambling, eventually confessing this in tears to a colleague. The tears didn't signal an end. He didn't stop placing bets so that he could pay his tax arrears instead. Gambling was in his soul.

To this day, I feel disinclined to take part in the National Lottery. No Thunderball for me. You don't see me at the bingo club either. Nor do I ever fancy Camira Flash - that's The Duke's dog, innit - or want to put twenty-five knicker on Yellow Printer, the dog that broke the record at White City last week. I don't even have a flutter on the Grand National. My prejudice is deep. I'm as unlikely to visit the betting shop as shoot cocaine.

All this is a far cry from the innocent joys of family cardplaying! All my life I have distinguished between card playing in that way, and 'serious' card playing - Bridge, mainly - at clubs. Or the racy gambling games like poker, which are now relentlessly pushed at punters, and which for a certain type of young man must be as dangerously addictive as fast red sports cars, and easy sex with young blonde girls in hotpants and exaggerated manga bodies. What a shame that for many people, especially young people, 'cards' are associated only with Texas Hold 'Em, and hammering the credit card balance at midnight in front of the computer.

Elsewhere on this blog I've described how I used to play cards with Dad. And how for three years after he died, I missed not playing our favourite games with him. Buying my Sony tablet last April has changed that. I can now have a game with an 'artificial intelligence'. This is what I have installed. (These are games for an Android device. You'd have different versions for an iPad)

BTO Cribbage by Buck The Odds, LLC (?1.28)
Ecart? by GoodSoft (free)
Piquet by GoodSoft (free)
Klondike Solitaire by Softick Ltd (free)

As you can see, these were mostly free. I'm sure you are familiar with Cribbage, and of course Solitaire. Ecart? was an Edwardian casino game, a bit like Whist with trumps but played with only five cards, in which you discard again and again to improve the hand before someone calls a halt and you play with what you've got. Piquet is a very old but highly skilful game, again on the lines of Whist, with a discarding stage, scores for sets and sequences, and a playout at No Trump. There is facsimile onscreen running commentary, because in the real game you speak as you play. In the example below, I'm 'Y' for 'Younger Hand' (i.e. the dealer). It's the fifth of six deals, and I've got a commanding lead already, but then I get this cracker of a hand. I think I won with over 300 points clocked up (the computer does the arithmetic):


With all but Solitaire you are playing for points against an opponent. I keep to 'moderate' difficulty with the two-player games. I can usually thrash my opponent at Piquet, because I've got a feel for the game. But Ecart? and Cribbage (with much more of an element of luck, good or rotten, in them) are harder, and I can feel more of a triumph if I win, or savour a sweeter revenge if I lose and then trounce my opponent in a return match. Complete with 'swivel on that' gestures. (Pointless of course, because there's really nobody there. But I get exasperated at the impossible luck the 'artificial intelligence' seems to enjoy all too often, and frankly he-she-it deserves much worse abuse than I give out!)

These are pretty good card games if you can seldom play anyone in real life. Computerisation makes them unnaturally slick, but the same fine judgements on the odds can be made, and you can play your hunches, just as in the real-life version. Softick's classy version of Solitaire is an absolute winner in my view. It has so many nice touches. Even a 'realistic' noise as you turn up cards, or send them onto different piles. And you can put the photo of your choice on the back of each card. I use Mr Punch, as in this photo I took in 2010:


If I'm doing nothing else, and feel inclined to play cards, as I might anytime during the day, I will challenge my opponent at Ecart? and Cribbage - or rather less often at Piquet (because it takes six long deals to win). That usually results in a satisfying tussle. Then I'll play Solitaire until I have clocked up three wins. 'Three-win Solitaire' is my regular bedtime mental exercise, and because the tablet is easy to hold or prop up, I can actually do this when snug in bed, whether that's in the house or away in the caravan.

The 'mental exercise' aspect is important. You can buy little gadgets that let you play Sudoku - pardon me, while I yawn and fall over at the thought of Sudoku - as bad as crosswords - anywhere, anytime, to keep your decrepid brain from seizing up. But I prefer Solitaire, or, for a bit more excitement and emotional expression, one of my other card games. Same function.

And is my brain in better shape? Or am I still going gaga? Reader, you must make up your own mind.

And if anyone recognises where the references to Yellow Printer, or Camira Flash (The Duke's dog, innit) come from, I will be mightily impressed with their Great Knowledge.

Source: http://lucymelford.blogspot.com/2012/09/card-games.html

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Source: http://railway-woodcutting.blogspot.com/2012/09/lucy-melford-card-games.html

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Source: http://uvyvuvo.posterous.com/railway-woodcutting-lucy-melford-card-games

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FYI Express: Flood Insurance Manual Changes October 1, 2012

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Source: http://fyi-express.blogspot.com/2012/09/flood-insurance-manual-changes-october.html

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Researchers determine how inflammatory cells function, setting stage for future remedies

Researchers determine how inflammatory cells function, setting stage for future remedies

Thursday, September 27, 2012

A research team led by investigators at New York University and NYU School of Medicine has determined how cells that cause inflammatory ailments, such as Crohn's disease, multiple sclerosis, and arthritis, differentiate from stem cells and ultimately affect the clinical outcome of these diseases.

"We've found that hundreds of new genes are involved in the function and development of these cells," said co-author Richard Bonneau, an associate professor at New York University's Center for Genomics and Systems Biology and the Courant Institute of Mathematical Sciences. "This expansion in our understanding can be used as a framework for designing new therapies to combat a range of ailments where the immune system attacks self."

These cells, called T-cells by immunologists, play a role in fighting off infection, but can also induce inflammation and other processes that damage tissues and contribute to several common inflammatory diseases. T-cells are also key cell types in new immune-cell based therapies for fighting cancer. There are many types of T-cells, and how they differentiate from stem cells in the human body lies at the center of understanding several diseases.

"We have been striving for several years to understand what makes inflammatory T-lymphocytes special," said lead investigator Dan Littman, MD, PhD, the Helen L. and Martin S. Kimmel Professor of Molecular Immunology and a professor of pathology, microbiology and molecular pathogenesis at NYU School of Medicine and a faculty member of the Skirball Institute on Biomolecular Medicine. "They can protect us from microbes, but they also have the potential to cause autoimmune disease.

"We were fortunate to be able to bring together a team of immunologists, computational biologists, and genomics experts to begin to solve this puzzle. Whereas before we only knew of a handful of genes that influence the function of these cells, we now know of hundreds of new ones that can serve as a resource for further studies by us and other laboratories. Our hope is that some of these new molecules will be the Achilles heel that we can target to treat these diseases."

The findings, which are reported in the latest issue of the journal Cell, lay the groundwork for understanding how these cells regulate their genomes through a regulatory network that connects many environmental stimuli to a large number of genes and their interactions. This large network model is essentially the brain that T-cell precursors, or stem cells, use to decide what they want to be when they grow up. Specifically, a network model can be used simulate what inhibiting a gene with a drug would do to different T-cells and, in this way, aid the development of new therapeutic measures to address these afflictions.

The study focused on T-helper 17 cells (Th17) and how they regulate the synthesis of gene products from thousands of regions of the chromosome. Th17 cells have previously been implicated in inflammatory diseases. Other studies have also identified hundreds of genes that roles in pro-inflammatory diseases. This new study places these implicated genes on a timeline of cellular development and ultimately puts them together in an integrated model of how genes interact.

To explore the inner workings of these cells, the researchers used a systems biology approach, which focuses measuring multiple biomolecules and capturing multiple interactions within an organism to understand how it functions. For example, each of the 450 data sets integrated in this study contained measurements of gene expression, chromatin structure, or gene-chromosome interaction that spanned millions of locations along the genome. This holistic method offers a broader understanding of interconnected molecular phenomena essential to running life's program?a process similar to studying an entire automobile while it functions rather than separately studying the headlights, brakes, or steering column.

To extract meaningful results from this very large data set, the researchers employed statistical techniques to uncover the network model from the large amount of data. To verify the accuracy of the computer modeling, further laboratory experiments were conducted using mice. Although the study was carried out in mice, the researchers found that their work could offer explanations as to why a large number of genes are associated with several human inflammatory diseases. The researchers' computer models identified candidate genes that influence the expression of more than 2,000 genes and play a significant role in the regulation of Th17 cells. They found that the core of this network was significantly enriched for the genes that human geneticists have found to be associated with pro-inflammatory disease. These genes serve as cogs in the regulation of expression or suppression of genes in Th17 cells and are potential leads for developing new therapeutic approaches to modulating inflammation.

###

New York University: http://www.nyu.edu

Thanks to New York University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/123909/Researchers_determine_how_inflammatory_cells_function__setting_stage_for_future_remedies

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Thursday, September 27, 2012

Why Horseracing Is So Well-liked ? Recreation and Sports

Sports are excellent, and engaging in it not only helps to reinvigorate the body but the mind as well. Indeed engaging in sports offers a lot of advantages. It can reduce stress and might often even help cure some types of illness. A lot of people nowadays are residing in a busy world and will work tirelessly to make money. It?s a good characteristic, but putting yourself into a lot of stress by operating too much might cause your body to break down. You should not only concentrate on building your job but you also need to become sports oriented and keep up with the needs of the physique and mind to become fit. You need to remember that tension can weaken the mind and physique. Exposing yourself to constant stress could avoid you from doing all of your daily routine. Actually when you watch a simple horse racing sport, your body encounters excitement and excitement like it would when you engage in it. It is important to unwind from time to time. Horseracing is a game that can provide a person that watches it a feeling like he?s actually the one riding on the horse. It?s a state that people get into if they want their bet to earn.

This type of game has been around since the ancient times and is still one of the most popular sports today. This kind of game has only already been used to entertain noble families, but now, the game can be watched by people of any kind of social status. This type of sports is so popular because it?s one of the games in which people are permitted to bet. It?s usually situated in a large stadium and can cater to thousands of family and friends. Many people particularly the rich ones, love to bet on their favourite horses and are usually following a system. They use a system that allows them to rule out fragile participants. The system helps them to slim down their choices and increase their probabilities of winning the game. Before the round begins, the bettor chooses his preferred horse; one that runs quick in any given terrain.

There are gambling stations in which gamblers may go to, if they want to wager on their favourite horse. The reason why horse racing in Australia is so well-liked by people is because the federal government created gambling lawful in this country. This type of betting game has been practiced before and is still used in this modern age.


Tags: horse racing in Australia, horseracing

Source: http://recreationandsports.emilie.org/uncategorized/why-horseracing-is-so-well-liked/

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Analysis: Obama-Romney debate challenge: handling the off-script moment

WASHINGTON (Reuters) - If history is a guide, Democrat Barack Obama will have a tough time in the first presidential debate on Wednesday, Republican Mitt Romney will be particularly aggressive, and both will risk committing a damaging gaffe if they wander off their talking points.

The 90-minute showdown in Denver - the first of three televised Obama-Romney encounters in October that will set the tone for the final month of the presidential campaign - will feature two experienced and competent debaters who are at their best in scripted settings.

Neither the Democratic president nor his Republican rival has ever seemed to enjoy the more freewheeling aspects of a candidates' debate, and both have said things during debates that became headaches for their campaigns.

Obama, known for soaring rhetoric and inspirational generalities in his speeches, suffered in some 2008 Democratic primary debates from a diffident and nuanced style that could make him seem flat and uncertain. His most pointed responses often seemed condescending or flippant.

Romney, who survived a grueling series of debates in this year's Republican race, often displayed an efficient and feisty style in rolling over his challengers.

But Romney also can seem stiff and awkward when challenged.

When frustrated, he can also make mistakes - like his offer to bet Texas Governor Rick Perry $10,000 over a disputed point during one Republican primary debate, a scene that was a reminder of critics' charges that Romney is an out-of-touch rich guy.

"They are pretty evenly matched as debaters," said Alan Schroeder of Northeastern University in Boston, who has written a history of presidential debates. "They both tend to be more intellectual than emotional, and they are both articulate and comfortable on camera. But they would both prefer to be in a more controlled setting."

The high-stakes debates - particularly the one on Wednesday, which will be moderated by PBS' Jim Lehrer and focus on domestic policy - could be the last chance for Romney to reclaim momentum from Obama.

The president leads his Republican rival in most national polls and in the politically divided "swing" states likely to decide the November 6 election.

Romney has taken frequent breaks from the campaign trail to practice for the debates, which could draw a television audience dwarfing the 30 million who watched his speech on the last night of the Republican National Convention last month.

The first of the three debates in the 2008 presidential race between Obama and Republican John McCain drew 52 million television viewers.

Debates rarely make a big difference in the final results of presidential races, but a strong performance can give a candidate a bump of a few percentage points in polls, said Mitchell McKinney, a political communications specialist at the University of Missouri.

"You don't normally see game-changer type moments in a presidential debate," he said. "But now the game is almost over, and this is Romney's chance. Can he take advantage?"

Both candidates are proven debaters, but have weaknesses that can be exploited, analysts said.

"If you are Romney, you want to figure out a way to get under Obama's skin, you want to see him get prickly," said Dan Schnur, an aide to McCain's 2000 presidential campaign. "If you're Obama, you want to be a little unpredictable and throw Romney off his script."

A CHALLENGE FOR OBAMA

Recent presidential debates suggest the first debate could be Obama's toughest.

Three of the last four incumbent presidents to seek a second four-year term - Ronald Reagan in 1984, George H.W. Bush in 1992 and his son George W. Bush in 2004 - suffered difficult first debates, although Reagan and the younger Bush won re-election.

The exception was Bill Clinton, a natural debater, in 1996. Clinton had defeated the elder Bush in 1992, and was a much sharper communicator than Kansas Senator Bob Dole, Clinton's Republican opponent in 1996.

"An incumbent president is used to having his way and being deferred to. He is not as used to being challenged," McKinney said. As a result, "they may come across as perturbed. Their job is to defend their record without becoming defensive."

That could prove tricky for Obama, who also will have to walk a fine line in acknowledging the nation's high unemployment rate and the economic difficulties faced by most Americans, while offering a more hopeful vision for the future.

During the 2008 debates, Obama sometimes sounded like the constitutional law professor he once was, exploring every angle of an issue in a rambling style. His staff says it is trying to curb those tendencies in debate preparations.

Obama was reminded of the danger of straying off message earlier this year when he punctuated a speech about the government help that business owners receive with the line, "You didn't build that."

Romney's Republicans called it an insult to business owners and made "We Did Build That" a theme not only of campaign commercials but the Republican convention.

Obama's most memorable 2008 debate gaffe came in what was widely viewed as an insensitive putdown of Democratic rival Hillary Clinton after a moderator questioned her likability.

"You're likable enough, Hillary," said Obama, who after his election appointed her as secretary of state.

Romney faces his own challenges on likability, and the trick for the former private equity executive will be to mount an aggressive attack on Obama without coming off as too cold, calculating or desperate.

"His problem is that people don't believe what he says," said Democrat Doug Hattaway, an aide in the presidential campaigns of Al Gore in 2000 and Hillary Clinton in 2008. "He delivers the lines fine, but the punches don't land the way they would if he was trusted more, so he comes off as more scripted."

During the primary debates, his offer of a $10,000 bet to Perry was not Romney's only out-of-touch moment.

During a debate in Nevada, he countered an attack on his use of a lawn service that employed illegal immigrants by saying that he had told the company, "I'm running for office, for Pete's sake, I can't have illegals."

ROMNEY'S GAFFE PROBLEM

On the campaign trail, Romney has unintentionally reminded voters of his wealth and privilege with comments about his friendship with NASCAR owners and his wife Ann's Cadillacs.

In what could be a turning point in the campaign, Romney was secretly recorded at a private fundraiser telling wealthy donors that the "47 percent" of Americans who do not pay taxes are "victims" who depend on the government for handouts and probably would never vote for him.

"Romney has shown a greater facility for gaffes and missteps, obviously," McKinney said.

Even so, Romney - who participated in more than 20 debates in the 2012 primaries and more than 15 during his unsuccessful run for the White House in 2008 - will be the most experienced presidential campaign debater ever to appear in a general election debate, McKinney said.

Romney will have far more camera time and a much bigger audience in a one-on-one debate with Obama than he did during the crowded primary debates. Analysts said he would need to articulate a sharper vision for the nation and avoid looking like he is merely trying to score debate points at every turn.

Gore learned that lesson the hard way in 2000, when he seemed to win the verbal jousting with George W. Bush but turned off viewers with his impatient demeanor and exasperated sighs when Bush was talking.

(Editing by David Lindsey and Peter Cooney)

Source: http://news.yahoo.com/analysis-obama-romney-debate-challenge-handling-off-script-220202862.html

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Streams Of Water Once Flowed On Mars; NASA Says Photos Prove It

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    Curiosity, 2012: NASA says that water shaped the rocks on the left, in a photograph taken by the Mars rover Curiosity. For comparison, the agency released an image of rocks from the Earth (right).

    NASA

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    Spirit, 2010: When NASA's Spirit rover got stuck in Martian sand, it proved to be a lucky break: The spinning wheel churned up soil that provided evidence of rocks formed in the presence of water.

    NASA

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    Opportunity, 2004: Opportunity discovered tiny mineral spheres ? nicknamed blueberries ? poking out of rocks that were likely formed by water. Researchers using Opportunity's science instruments identified them as concretions rich in the mineral hematite, deposited by water saturating the bedrock.

    NASA

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    Pathfinder, 1997: The first mission to land a rover on Mars, Pathfinder touched down in Ares Vallis, an ancient flood plain in the planet's northern hemisphere. Among the 2.3 billion bits of data sent back by the lander and its rover, Sojourner, were 15 chemical analyses of rocks and soil, which suggested Mars had once had liquid water and a thicker atmosphere.

    NASA

NASA's Curiosity rover has found definitive proof that water once ran across the surface of Mars, the agency announced today. NASA scientists say new photos from the rover show rocks that were smoothed and rounded by water. The rocks are in a large canyon and nearby channels that were cut by flowing water, making up an alluvial fan.

"You had water transporting these gravels to the downslope of the fan," NASA researchers say. The gravel then formed into a conglomerate rock, which was in turn likely covered before being exposed again.

The agency's scientists presented their findings of the former streambed on Mars at a news conference today.

"A River Ran Through It," Curiosity's operators tweeted Thursday. "I found evidence of an ancient streambed on Mars, similar to some on Earth."

"From the size of gravels it carried, we can interpret the water was moving about 3 feet per second," said Curiosity science co-investigator William Dietrich, "with a depth somewhere between ankle and hip deep."

The rocks have not undergone scientific analysis. But the NASA team says that taken with geographic data from Mars orbiters, the photographs tell a story all their own.

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The images show rocks with round, smooth surfaces; many of them have been broken down into sizes smaller than one inch in diameter.

"The shapes tell you they were transported and the sizes tell you they couldn't be transported by wind," co-investigator Rebecca Williams said. "They were transported by water flow."

Scientists have not yet estimated the age of the rocks, which may have been buried beneath the surface. Their age could be several billion years.

The photographs released Thursday are among more than 13,000 raw images Curiosity has captured.

"There is earlier evidence for the presence of water on Mars," the agency said in a press release, "but this evidence ? images of rocks containing ancient streambed gravels ? is the first of its kind."

The next step will be to find a good spot to drill into the rock, NASA says. And they'll be looking for possible carbon deposits, to determine whether the water on Mars once supported life.

The Curiosity rover took the photos during its mission to Mars' Gale Crater. The rocks lie between the crater's north rim and Mount Sharp, a mountain inside the crater.

NASA investigators presented the results of their analysis at NASA's Jet Propulsion Laboratory in Pasadena, Calif.

Source: http://www.npr.org/blogs/thetwo-way/2012/09/27/161896238/streams-of-water-once-flowed-on-mars-nasa-says-photos-prove-it?ft=1&f=1007

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Wednesday, September 26, 2012

Thread: skill saw get new home - Family Woodworking - Yes ...

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Source: http://jeffersonboyce.typepad.com/blog/2012/09/thread-skill-saw-get-new-home-family-woodworking.html

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Source: http://edgarsapien1.blogspot.com/2012/09/thread-skill-saw-get-new-home-family.html

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Source: http://veil-backscratching.blogspot.com/2012/09/thread-skill-saw-get-new-home-family.html

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Source: http://goodmandeandre.typepad.com/blog/2012/09/thread-skill-saw-get-new-home-family-woodworking-yes.html

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Albert Nagy appointed as member of the Editorial Advisory and ...

Albert Nagy, professor of accountancy, was recently appointed as a member of the 2013-2015 Editorial Advisory and Review Board for Issues in Accounting Education.

Issues in Accounting Education is one of the three primary publications of the American Accounting Association. The mission of the journal is to publish research, commentaries, instructional resources, and book reviews that assist accounting faculty in teaching and that address important issues in accounting education.

Nagy is a CPA in Ohio, and a member of the American Accounting Association, Institute of Internal Auditors, and the American Institute and Ohio Society of Certified Public Accountants. His primary teaching interest is auditing. His research interests include audit quality, earnings management, financial statement fraud, auditor industry specialization, internal audit, and executive compensation. He has published articles in a several leading accounting journals, including Accounting Horizons, Auditing: A Journal of Practice and Theory, Research in Accounting Regulation, The International Journal of Accounting, Managerial Auditing Journal, and The Ohio CPA, and has made several academic presentations at national and regional meetings throughout the United States.

Source: http://sites.jcu.edu/boler/2012/09/25/3025/

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'Today' producer angry about Lauer stories

FILE - This April 24, 2012 file photo shows NBC "Today" show co-host Matt Lauer attending the TIME 100 gala, celebrating the 100 most influential people in the world, at the Frederick P. Rose Hall in New York. The "Today" show's top producer is speaking out against stories portraying anchor Matt Lauer as being difficult to work with during the show's slide in the ratings. Executive Producer Jim Bell said Wednesday that Lauer is the heart and soul of NBC's morning news show and that negative stories about him have been hard to deal with. "Today" has slipped behind ABC's "Good Morning America" in the ratings recently, particularly since Lauer's former co-host, Ann Curry, was replaced by Savannah Guthrie. That's led to a wave of bad publicity, much of it focused on Lauer. (AP Photo/Evan Agostini, file)

FILE - This April 24, 2012 file photo shows NBC "Today" show co-host Matt Lauer attending the TIME 100 gala, celebrating the 100 most influential people in the world, at the Frederick P. Rose Hall in New York. The "Today" show's top producer is speaking out against stories portraying anchor Matt Lauer as being difficult to work with during the show's slide in the ratings. Executive Producer Jim Bell said Wednesday that Lauer is the heart and soul of NBC's morning news show and that negative stories about him have been hard to deal with. "Today" has slipped behind ABC's "Good Morning America" in the ratings recently, particularly since Lauer's former co-host, Ann Curry, was replaced by Savannah Guthrie. That's led to a wave of bad publicity, much of it focused on Lauer. (AP Photo/Evan Agostini, file)

FILE - This April 24, 2012 file photo shows NBC "Today" show co-host Matt Lauer attending the TIME 100 gala, celebrating the 100 most influential people in the world, at the Frederick P. Rose Hall in New York. The "Today" show's top producer is speaking out against stories portraying anchor Matt Lauer as being difficult to work with during the show's slide in the ratings. Executive Producer Jim Bell said Wednesday that Lauer is the heart and soul of NBC's morning news show and that negative stories about him have been hard to deal with. "Today" has slipped behind ABC's "Good Morning America" in the ratings recently, particularly since Lauer's former co-host, Ann Curry, was replaced by Savannah Guthrie. That's led to a wave of bad publicity, much of it focused on Lauer. (AP Photo/Evan Agostini, file)

(AP) ? The "Today" show's top producer on Wednesday defended Matt Lauer against stories that have portrayed the anchor as difficult to deal with during the show's slide in the ratings.

The longtime morning champ has slipped behind ABC's "Good Morning America" in the ratings over recent months, after more than 15 years of being the unquestioned leader in the morning. The new ratings order has solidified since Ann Curry's tearful exit as Lauer's co-host in June.

"Matt has been the heart and soul of the show for a long, long time, and any of the stuff out that has portrayed him in an unflattering light as being difficult to work with is patently false and it's been tough to deal with," said Jim Bell, "Today" executive producer.

One tabloid report last week described Lauer as an "anchor animal" who berates the staff and inserts himself into show decisions, which Bell described as "patently false." He also denied an online report that Lauer would be asked to take a pay cut if the show's ratings don't improve. "Today" has also consistently shot down stories that Lauer played a behind-the-scenes role in Savannah Guthrie's replacement of Curry.

Asked if viewers were taking Curry's dismissal out on "Today," Bell said that "it's more complex than that."

"Any time there is a change, especially in the morning, it takes a while for people to process that change and we're still going through that," Bell said. "That's OK. We understand. We get it. We love our team and we really feel positive about the show we are doing and we are taking the long view here."

"Today" has actually taken pride in seamless anchor transitions in the past, such as when Meredith Vieira replaced Katie Couric, Curry replaced Vieira and Lauer took over for Bryant Gumbel. This one hasn't worked, at least for now.

Bell denied reports that he would leave "Today" for another job at NBC, saying "this is the best job in the world."

After a 17-year winning streak in the ratings, "GMA" overtook "Today" during a couple of weeks last spring. With the exception of two weeks when "Today" broadcast from the London Olympics, the ABC show has won consistently since Curry's dismissal, by margins as much as 800,000 viewers.

"GMA" has succeeded with a lighter, more pop culture-oriented show. Its on-air team of George Stephanopoulos, Robin Roberts, Josh Elliott and Lara Spencer has clicked during NBC's turmoil. "Today" has long been a huge cash cow for NBC, and a permanent change in the morning's pecking order would have big financial implications.

"For a long time, they tried to do a version of the 'Today' show," Bell said of ABC. "It didn't work well, so they have tried to do a different show. We are different shows right now. Despite however that might be working in the short term, for our show, it's in our best interests to be who we are and not try to do what someone else is doing."

Asked for comment, ABC spokesman Jeffrey Schneider said: "I think the audience has spoken loud and clear about its preference in the morning."

He said "Today," which featured a Curry interview with Libyan President Mohammed Magarief on Wednesday, will be making its differences with "Good Morning America" more apparent in coming months.

"While we recognize in the short term we're going through a difficult period, we're not going to compound it by suddenly doing a different show from the one we all feel good about, which is a smart show, a relevant show and an important show to do," he said.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2012-09-26-TV-Today-Lauer/id-e473527fbcff4dd48d5992546b62a423

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Tuesday, September 25, 2012

Federal financial toolkit aims to get Canadians out of debt | Debt ...

OTTAWA ? Ottawa believes Canadians might need a little help in how they spend and save.

The federal government has released a ?Financial Toolkit? that it says can help Canadians make sense of everyday financial questions they face.

The toolkit, which is available online and in printed form, includes worksheets, quizzes, questionnaires, case studies and educational videos to educate Canadians on making rational, responsible money decisions.

The toolkit was created in partnership with the Financial Consumer Agency of Canada, the Investor Education Fund and l?Autorite des marches financiers.

The initiative is part the government?s efforts to promote financial literacy and follows months of warnings from the Bank of Canada as well as the finance minister about the record high levels of consumer debt.

On a national basis, the average household debt stands at 152% of disposable income, just shy of the 160% level that was reached in the U.S. and the United Kingdom prior to the housing market collapse in 2008.

Economists have said that the high levels of consumer debt are a consequence of low interest rates that have been in place since 2008 as part of efforts to stimulate the economy by making it less expensive to borrow and spend.

Junior finance minister Ted Menzies says the toolkit is another way Canadians can acquire life skills.

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Source: http://business.financialpost.com/2012/09/25/ottawa-issues-financial-toolkit-to-help-canadians-get-out-of-debt/

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Analysis: For Romney, some troubling signs among older voters (reuters)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/250530136?client_source=feed&format=rss

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Healing of ours family tree - HolyLandPrayer.com

Please pray for all of us. We need God?s help in many areas of our marriage anf family life. please pray also for honest activity inc.financial of my husband?s work partner Steve and his family. Ask JESUS to protect us i every possible way and if we need forgive to each other, healing of our wounds and all needed Holy Spirit gifts.Please pray also for deceased and all names who i will quietly mention Our Heavenly Father.One more ? please delivere my special prayer (it is to long to write)but the title is -PRAYER FOR ENEMIES and directly to GOD-FATHER.Our LADY OF QEEN OF THE WORLD and HOLY LAND -pray for us.THANK YOU.

By Marianna
9/25/2012

Source: http://www.holylandprayer.com/prayer-list/healing-of-ours-family-tree/

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Monday, September 24, 2012

Belgraders Dub New Bins a Wasted Opportunity :: Balkan Insight

The woman carrying a garbage bag approaches one of Belgrade?s newest additions ? an underground bin. Unable to squeeze her family?s trash through what seems like too small a hole - and ignoring the sticker on the side of container that reads, ?Dumping trash next to the container is prohibited,? - she leaves her bag beside the new container.

?You can only dump small bags here, as nothing bigger can go through the hole,? she complains. ?I can?t say that this was a clever invention.?

She is not the only one to complain about the city?s latest innovation in the field of waste disposal.

Many people believe that although underground waste containers in theory are cleaner and more practical than the old, above-ground bins, the newcomers clearly have their shortcomings.

In response to such complaints, Gradska cistoca, the city?s public utility company, told BIRN that the underground containers were installed with a view to improving the city?s overall hygiene.

The containers were chosen on the basis of the experience of other European cities, where they had turned out to be ?the best solution to improve hygiene and to collect waste,? the company said.

The city decided to install underground garbage bins back in 2009. Since then, about 2,000 have been put in place around town. Belgrade plans to install another 4,000 by the end of 2013.

The first tranche of 2,000 cost about ?7 million.

Gradska cistoca caused some controversy over the consortium of two companies that it hired for the job.

Blok, a Belgrade-based company, had no previous experience in this field.

Blagojevica, a firm from Mladenovac, did have some experience. But its founder, Zivko Radojicic, was the owner of several previously bankrupted companies.

Most people in Belgrade appreciate the fact that the new containers save space and are less malodorous. At the same time, many say the containers should have been designed more carefully.

?This was good idea, but it?s been poorly implemented. You cannot dump anything larger than a small bag and the bags often get stuck in the hole,? Marko, a bartender, says.

Some say the new containers don?t meet the hygienic bar, either. ?They?re better than the old containers, but they should have chosen containers that can be opened by foot, as the shutters are often dirty and it?s greasy to touch them with your bare hand,? Andrea, a pensioner, complains.

The new underground waste containers also do not contain any potential for recycling, as they are not designed for the separation of the contents into recyclable components.

Katarina Pavlovic, from Serbian Green Youth, an NGO, says that although the new containers do have advantages compared to the old, above-ground containers, they don?t resolve the root problems involved in waste collection.

?We still have an issue with waste management,? she says.

?If there is no system to allow the separation of waste and recycling, if non-recyclable and recyclable waste ends up in the same container, there are no systematic differences between the underground and above-ground containers,? she maintains.

?Thus, despite all the new investment, recycling has remained an unresolved issue,? Pavlovic continues.

Another problem with the 7-million-euro-worth investment is that the containers are permeable, although they supposed to be waterproof.

?In some locations, the water leaks in when it?s raining,? one Gradska cistoca staffer admitted.

He added that, when it rains, the Gradska cistoca teams that empty the containers need assistance from another team, which pumps water from the containers into a tank.

?In these situations, it takes much more time to empty the container,? the same worker added.

City cleaners say it is yet to be seen how the containers will withstand prolonged wet weather, as most of them were only put in place in the spring and summer, when it was dry.

Gradska cistoca declined to answer any further questions from BIRN regarding this and other quality-control issues, as did representatives of the consortium hired to produce and deliver containers.

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Source: http://www.balkaninsight.com/en/article/belgraders-dub-new-bins-a-wasted-opportunity

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Egypt president stresses Syria resolve

(AP) CAIRO - Egypt's president on Saturday stressed the need for his country to have a bigger role in international affairs, using his first local television interview to urge the Syrian government to end the carnage coursing through Cairo's onetime ally.

"The Syrian regime needs to understand that the continuation of bloodshed goes against all laws, desires, history and humanity," Mohammed Morsi said in the hour-long interview, broadcast on state TV.

The one-on-one interview addressed a range of issues facing the new president, who was sworn into office on June 30 in the country's first free presidential elections. He assumed the post after a rocky transitional period governed by the country's military, which took power after last year's uprising that ousted longtime President Hosni Mubarak.

Egypt's uprising inspired others in the region, including in Syria.

"Egypt is not on the sidelines of this problem. There is a positive and personal relationship between the Egyptian people and the Syrian people," Morsi said, in a reference to the shortly-lived alliance that ended in 1961 between Egypt and Syria, when both nations shared the same flag as part of a union. "The Syrian struggle pains us now, pains all people of the region."

Rebels move command center from Turkey to Syria
Assad: Syrian rebels will be defeated

Syria's bloody 18-month conflict, which activists say has killed nearly 30,000 people, has so far eluded attempts at international mediation.

Morsi has launched an "Islamic Quartet" of regional powers to seek an end to the violence, bringing together Egypt, Turkey, Saudi Arabia and Iran.

However, the quartet faces deep divisions. Sunni led Egypt, Turkey and Saudi Arabia have called on Syrian President Bashar Assad to step down, while Shiite Iran firmly backs him. Saudi Arabia and Iran are also bitter rivals with longstanding disagreements over Gulf security issues.

"I do not believe Iran's presence in the group is part of the problem, but part of the solution" Morsi said, adding that he hopes the four nations along with other countries can meet "at the highest level" on the sidelines of the U.N. General Assembly meeting later this month.

Morsi, who is scheduled to travel Sunday to New York for the U.N. meetings, has been criticized by some in Egypt for focusing too much on foreign affairs and doing little to address Egypt's internal challenges.

In the interview, he explained that in order to help Egypt domestically, he needs to reach out to other nations, particularly in Africa, and increase investments from the West and China to help build the country.

While he did not discuss Israel, with which Egypt has a decades-old peace treaty following years of war, Morsi said that "there cannot be peace in the Middle East without giving Palestinians their full rights."

"This is what the peace treaty was based on ? a full and balanced (regional) peace," he said, referring to the 1979 accord that ended decades of hostility between Egypt and Israel, but did not contain the conflict between Palestinians and Israelis.

"Egyptians are always and will always be supportive of their Palestinian brothers, all Palestinians," he said. Palestinian militant group Hamas, which rules the Gaza Strip, is itself an offshoot of Morsi' Muslim Brotherhood group, which has long rallied for Palestinian statehood.

Earlier on Saturday, Egypt's Supreme Administrative Court upheld last summer's ruling that dissolved parliament just days before Morsi was declared victor in the elections.

The ruling means that Morsi now maintains legislative powers in the absence of parliament, after the forced retirement of generals with which he previously shared powers.

"I will not use my legislative powers except in a very limited framework," he said in the interview.

Source: http://feeds.cbsnews.com/~r/CBSNewsWorld/~3/kAmgd32157A/

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Long-term outcomes after RP as first-line therapy for men with cT3 ...

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We have no data from randomized trials on the relative effectiveness of surgery compared to radiation therapy in the treatment of men initially diagnosed with clinical stage T3NxM0 prostate cancer. However, we do now have data from > 800 men treated with radical prostatectomy (RP) and followed for up to 23 years at the Mayo Clinic.

Mitchell et al. conducted a retrospective analysis of data on the thousands of men treated by radical prostatectomy at the Mayo Clinic between 1987 and 1997. Based on that analysis, they offer the following information:

  • 843 men were treated by first-line radical prostatectomy alone after a diagnosis of clinical stage T3NxM0 disease.
  • Average (median) post-surgical follow-up was 14.3 years (range 0.1 to 23.5 years).
  • 223/843 patients (26.5 percent) were found to have pathological T2N0M0 disease post-surgery.
  • At an estimated follow-up of 20 years (based on Kaplan-Meier methodology)
    • Local recurrence-free survival for all patients was 76 percent.
    • Systemic progression-free survival for all patients was 72 percent.
    • Prostate cancer-specific survival for all men 81 percent.
  • On multivariate analysis, an increased risk for prostate cancer-specific mortality was evident in men with
    • Higher pathological Gleason scores (hazard ratio [HR] = 1.8)
    • Non-diploid chromatin content (HR = 1.8)
    • Positive surgical margins (HR = 2.1)
    • Seminal vesicle invasion (HR = 2.1)
  • A more recent year of surgery was associated with a decreased risk of cancer-specific mortality (HR = 0.88).

Mitchell et al. conclude that:

  • ?RP affords accurate pathological staging and may be associated with durable cancer control for cT3 prostate cancer, with 20 years of follow-up.?
  • ?RP as part of a multimodal treatment strategy therefore remains a viable treatment option for patients with cT3 tumors.?

However, they are also careful to note that external beam radiation therapy in combination with androgen deprivation therapy offers 10-year progression-free survival among about 88 percent of men when given as first-line therapy for men initially diagnosed with cT3 disease. The combination of radiation therapy and ADT may well (therefore) be the most appropriate form of treatment for older men initially diagnosed with cT3 disease.

The bottom line is that for those men with what may be the earliest stages of cT3 disease on diagnosis (and who may therefore turn out to have pT2 disease post-surgery) ? and particularly for younger men who may be able to recover well after radical prostatectomy ? surgery is still a very appropriate form of first-line treatment that can always be followed later with adjuvant or salvage radiation therapy (with or without ADT, as necessary). Careful patient selection and a thorough discussion of the risks and benefits of such an approach are clearly key factors in the application of such a clinical strategy.

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Source: http://prostatecancerinfolink.net/2012/09/24/lon-term-outcomes-after-rp-as-first-line-therapy-for-men-with-ct3-disease-at-time-of-diagnosis/

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